Application of Pantoprazole Pantoprazole 40 mg:
duodenal ulcer or gastric in acute phase, including associated with taking NSAIDs, or refractory to therapy blockers histamine H2-receptors, gastroesophageal reflux disease (moderate and severe forms); Zollinger – Ellison, combined H. pylori eradication therapy in patients with peptic ulcer disease in order to reduce the frequency of relapses.
Contra Pantoprazole 40 mg:
Hypersensitivity, hepatitis and cirrhosis, accompanied by severe hepatic insufficiency.
Restrictions apply Pantoprazole 40 mg:
liver function abnormalities, children’s age (experience of use in children under 6 years of absence).
Application of Pantoprazole in pregnancy and breastfeeding: When pregnancy is possible only under strict indications, when the benefits to the mother justifies the potential risk to the fetus. At the time of treatment should stop breastfeeding.
Side Effects Pantoprazole 40 mg:
From the digestive tract: diarrhea, rarely – dry mouth, increased appetite, nausea, belching, vomiting, flatulence, abdominal pain, constipation, increased transaminases, gastrointestinal carcinoma (single case).
The nervous system and sensory organs: a headache, rarely – fatigue, dizziness, drowsiness, insomnia, and in some cases – anxiety, depression, tremor, paresthesia, photophobia, blurred vision, tinnitus.
With the genitourinary system: in rare cases – Hematuria, edema, impotence.
Co the skin: in rare cases – alopecia, acne, exfoliative dermatitis.
Allergic reactions: seldom – rash, urticaria, pruritus, angioedema.
Other: rarely – hyperglycemia, myalgia, and in rare cases – fever, eosinophilia, hyperlipoproteinemia, hypercholesterolemia.
Connectivity Pantoprazole 40 mg:
Can reduce the pH-dependent absorption of ketoconazole and other drugs. Compatible with drugs metabolized with the participation of the enzyme cytochrome P450 (phenazepam, diazepam, digoxin, theophylline, carbamazepine, diclofenac, naproxen, piroxicam, phenytoin, warfarin, nifedipine, metoprolol, ethanol. Does not affect the effectiveness of hormonal contraceptives.
Overdose Pantoprazole 40 mg:
Symptoms: not described.
Treatment: If overdose is suspected, we recommend conducting a supportive and symptomatic therapy. Dialysis is ineffective.
Dosing and dose Pantoprazole 40 mg:
Inside. Monotherapy with gastric ulcers and duodenal ulcers, gastroesophageal reflux disease – usually 40 mg / day is possible (increasing the dose) to 80 mg / day (especially when erosive and ulcerative forms of reflux esophagitis). Duration of the course in duodenal ulcer – 14 days (sometimes up to 2 weeks), gastric ulcer and gastroesophageal reflux disease – 4 weeks (in some cases, for another 4 weeks).
Combined H. pylori eradication therapy in patients with gastric ulcer or duodenal ulcer – 40 mg 2 times daily (before breakfast and before dinner or during a meal, without chewing, and without destroying the integrity of pills, washed down with fluid) in combination with amoxicillin (1000 mg 2 twice daily) and clarithromycin (500 mg 2 times a day), or with metronidazole (500 mg 2 times a day) and clarithromycin (500 mg 2 times a day). Duration of the course of eradication therapy – 7 days (maximum of 2 weeks).
Precautions Pantoprazole 40 mg:
Before starting treatment should be excluded malignant disease of the esophagus and stomach (symptomatic improvement may delay the correct diagnosis and treatment). The diagnosis of reflux disease should be confirmed endoscopically. Not recommended for patients with non-ulcer dyspepsia. In elderly patients and impaired renal function do not exceed the recommended dose of 40 mg / day. In severe hepatic impairment dosing regimen should be adjusted: 1 tablet. each 2-day, under the control of liver enzymes (with its increase is shown lifting the drug).
